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Chunk #24 — Results — Polygenic Scores

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Clinical, genomic, and neurophysiological correlates of lifetime suicide attempts among individuals with alcohol dependence.
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Figure 1 (Panel B) shows conditional PGS results from the multinomial logistic models comparing those with AD who had attempted suicide (AD+, SA+), those with AD who had not attempted suicide (AD+, SA−), and those without AD who had attempted suicide (AD−, SA+) to those without an AD diagnosis and who had not attempted suicide (full results in Table S9. The AUD (ORMETA = 1.16, 95% CI = 1.05, 1.28), DEP (ORMETA = 1.29, 95% CI = 1.16, 1.44), SMOK (ORMETA = 1.30, 95% CI = 1.17, 1.44), and SUI (ORMETA = 1.40, 95% CI = 1.22, 1.60) PGSs were all associated with increased odds of being in the AD+, SA + group. Interestingly, the only differences in results between the AD+, SA + group and the AD+, SA− group was in the DEP and SUI PGSs, while the only differences in results between the AD+, SA + group and the AD−, SA+ group was in the AUD PGS.