Genetic correlation between the European-ancestry PGC and iPSYCH GWAS results was calculated using LD Score regression37. The regression was performed using pre-computed LD scores for HapMap3 SNPs calculated based on 378 European-ancestry individuals from the 1000 Genomes Project (see URLs). Only results for markers with an imputation INFO score > 0.90 were included in the analysis. In addition, a bivariate GREML analysis was conducted using GCTA120 in order to estimate the genetic correlation between PGC case/control and trio study designs.
