In general, reading the values of from each model, we find that a rare (K = 0.01) recessive disease model produces higher power compared to common (K = 0.1 or 0.2), co-dominant or dominant disease models. Meanwhile, high R value (0.9 or 1.0) also helps increase dTDT’s ability to detect signals. This is because in a rare recessive case, markers with high LD to the disease allele both parents are heterozygous and both transmit the recessive risk allele to their offspring. Our findings from the simulation validate what we already observed in the biological phenomenon.
