applied to all the P-values for the datasets not genotyped by Immunochip or Metabochip. Additionally, genomic control was skipped for one dataset that did not have full associations available75 and for all the datasets from the GIANT consortium because genomic control had already been applied for these. In total, 1,263 summary statistics files were added to the analysis. Information about the summary statistics files can be found in the Supplementary Note and Supplementary Table 13.