While accounting for ADH1C is most relevant to testing the effect of ADH1B*3, there is also evidence for the influence of other ADH genes on alcohol dependence risk, including ADH4 (Edenberg et al., 2006), ADH5, and ADH7 (Luo et al., 2006). Molecular genetic studies of alcohol dependence risk are increasingly incorporating a range of ADH genes to test their joint and unique effects (Edenberg, 2007). An important direction for future studies of genetic influences on behavioral and psychological factors, such as alcohol response, is to examine a broader range of ADH genes in order to examine the distinct contribution of each and test for potential gene-gene interactions.
