Illumina Human670QuadCustom Beadchip and HumanHap610-Quad SNP array (Illumina, San Diego, CA, USA) were used for genotyping of common single-nucleotide polymorphisms (SNPs) genome-wide at the Welcome Trust Sanger Institute, Cambridge, UK for the CRIME and control cohorts, respectively. Stringent quality control was used and only SNPs originally included in all data sets of controls and cases were analyzed, resulting in 481866 SNPs in the final data set. Targeted genotyping for both controls and cases were performed by Sequenom MassARRAY iPLEX technology (San Diego, CA, USA) simultaneously at the Institute for Molecular Medicine, Finland (for details on genotyping, see Supplementary Information).
