AD. ReHo has been speculated to be a biomarker of disease progression in patients with AD and MCI (He et al., 2007; Zhang et al., 2012). FC evaluates the interregional connectivity between spatially remote brain regions. Functional interactions between distinct regions also play a crucial role in cognitive processing and, similarly, altered patterns of FC is a proposed biomarker of AD and MCI (for a review, see van den Heuvel and Pol, 2010).
