Chunk #51 — Methods — SNP-heritability (h2SNP).

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

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We estimated h2SNP based on the liability-scale (population prevalence estimates of 0.125) for common SNPs mapped to HapMap386 using LDSC.46 For AA and LA, we created in-sample LD scores derived from the MVP genotype data using cov-LDSC.87