Chunk #15 — 3. Results — 3.1. Systemic treatment with PPARα activators activates PPARα in brain

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Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.

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We first examined whether systemically administered Wy-14643 and fenofibrate activate PPARα at the protein level in brains. EMSA showed that both PPARα activators increased the amount of active PPARα protein in the nuclear fraction that was obtained from the brains without LPS injection (Fig. 2).