Chunk #16 — 3. Results — 3.2. PPARα activators elevate PPARα mRNA in brain

Source

Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.

Embedded

yes

Text

We measured the influence of Wy-14643 and fenofibrate on mRNA levels of PPARα and several pro-inflammatory molecules in the brains that were not injected with LPS. PPARα was significantly elevated by Wy-14643 and fenofibrate, both at 30 mg/kg (Fig. 3A).