on alcohol, stimulants or nicotine was evident in any group. Fifth, alcoholics DAO and DASD (combined STAA and LTAA) did not differ on any cognitive measures that showed impairment in STAA vs. NSAC. Finally, in LTAA, individuals with a cocaine disorder had lower volumes of the accumbens, hippocampus and thalamus than those with a methamphetamine disorder, suggesting that the inflammation secondary to a cocaine disorder may resolve with long-term abstinence while that due to a methamphetamine disorder does not.