Chunk #143 — IV. Results of tests of clustering within individual samples and tests of convergence between replicate samples for the same phenotypes — D. Frontal brain volume (Samples 10 and 11)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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5786 SNPs provide nominally-positive results in 100k Affymetrix data from Framingham samples (REF). 2729 of these nominally-positive SNPs fall into 613 chromosomal clusters with at least 3 SNPs that lie within 100 kb of each other. Monte Carlo trials do not identify this degree of clustering in any of 100,000 simluation trials (thus p <0.00001).