We hypothesized that individuals in the extreme of the GPS distribution might have an increase in BMI that approaches or exceeds the 4.1 kg/m2 increase noted for carriers of pathogenic MC4R mutations, and tested progressively more extreme tails of the distribution. The top 1.6% of the GPS distribution had a mean BMI 4.1 kg/m2 higher than the remaining 98.4% – 31.4 versus 27.3 kg/m2, and 9.1% of these individuals were severely obese.
