lead to opioid dependence. The neuroticism PRS showed positive associations with ODunexposed and ODexposed phenotype comparisons. Although it was non-significant, we observed a negative association of neuroticism PRS with the OEcontrols phenotype. This suggestive negative relationship parallels the rs9291211 result where the allele A was associated with reduced OE in the PGC GWAS meta-analysis and increased neuroticism score in the UK Biobank. Genetic liability to neuroticism may thus overlap with genetic liability to OD but not to OE.
