Chunk #54 — Methods — Differential expression analysis — Public data comparison and enrichment analysis

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Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry.

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For public data comparison, we downloaded the ancestry-associated DEGs in immune cells18 and immune function GWAS prioritized genes33–35. We assessed enrichment with our ancestry-associated DEGs using a two-sided Fisher’s exact test and corrected for multiple testing with the Benjamini–Hochberg method.