To understand the cellular context of ancestry-associated DEGs in the human brain, we performed cell type enrichment analysis by leveraging existing gene expression data from 39 broad categories of cell types from the mouse central and peripheral nervous system23. Specifically, we examined the overlap between DEGs and cell-type-specific genes for each cell type defined in a previous study75. We assessed enrichment for each brain cell type using a two-sided Fisher’s exact test. We corrected for multiple testing with Benjamini–Hochberg method.
