A prior history of SA was not associated with onset of alcohol, nicotine or cannabis use (OR = 1.04 – 1.19; Table 6). However, a prior history of SA was associated with 1.44 – 1.61 adjusted odds of onset of alcohol, nicotine and cannabis dependence. Similar to results for Model 2, males with SA were more likely than their female counterparts to meet criteria for cannabis dependence (Table 4). Also, like in Model 2, MDD (OR = 0.47 – 0.70), externalizing disorders (OR = 1.30 – 2.30) and family history of alcohol use disorders, particularly having two parents with alcohol use disorder (OR = 1.73 – 2.32), were the strongest correlates of onset of substance use and dependence (Supplemental Table S7).
