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Chunk #26 — 4. Methods — 4.4. Data Processing and Analysis

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Frontoparietal connectivity in substance-naïve youth with and without a family history of alcoholism.
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For within-group examination of normalized voxelwise correlation values that significantly differed from zero, single sample t-tests were performed (AFNI 3dttest) for each group. Independent sample t-tests determined significant group differences in time series seed-voxel correlations (AFNI 3dttest). Correction for multiple comparisons was achieved through a Monte Carlo simulation, indicating only clusters ≥ 648 μl (or 24 contiguous voxels) with a z-score > 2.02 would be interpreted, for an overall volume alpha = .05.