GWAS meta-analysis of ADHD revealed the first genome-wide significant risk loci, and indicates an important role for common variants in the polygenic architecture of ADHD. Several of the loci are located in or near genes that implicate neurodevelopmental processes that are likely to be relevant to ADHD, including FOXP2, SORCS3, and DUSP6. Future work may focus on refining the source of the strong association in each locus, especially the lead locus on chromosome 1 which is complicated by broad LD and substantial heterogeneity between ADHD the main meta-analysis and analysis of self-reported ADHD status in 23andMe.
