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Chunk #48 — ONLINE METHODS — Data acquisition, quality control, and normalization — Gene Expression, DNA Methylation, Histone Modification QTL Mapping.

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Integrative transcriptome analyses of the aging brain implicate altered splicing in Alzheimer's disease susceptibility.
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The details of ROSMAP gene expression, DNA methylation, and histone modification data are described in Supplementary Notes. The quantitative trait locus (xQTL) analysis on a multi-omic dataset is described in Ng et al.29. The xQTL results and analysis scripts can be accessed through online portal, xQTL Serve (see URLs).