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Chunk #39 — 2. Methods and Materials — 2.4. Statistical Methodology — 2.4.2. Age variation of genotypic effects — Identification of Significant SNPs

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Genetic correlates of the development of theta event related oscillations in adolescents and young adults.
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Specifically, the distribution of p-values from non-associated SNP-phenotype pairs should be uniform on the interval from 0 to 1, while the the distribution of p-values from associated SNP-phenotype pairs should be concentrated near 0. From the estimation of the occurrence of non-associated SNP-phenotype pairs, it is possible to estimate the occurrence of associated SNP-phenotype pairs, and determine the false discovery rate, sometimes called a q-value, as a function of thresholding at different p-values. As with any thresholding technique, choice of a threshold is arbitrary, and the correspondence between p-values and q-values for levels q < .05 and q < .01 are provided. This procedure is appropriate for the evaluation of all obtained p-values collectively, as the algorithm deals with correlated values appropriately. This provides information on a fine-grained time scale. However, given the large number of central ages at which the regression calculations were performed, in the interest of condensation of information and ease of interpretation results are also provided for 7 overlapping 3 year age ranges extending from age 12 to 24. (Ranges: 12–15, 13.5–16.5, 15–18, 16.5–19.5, 18–21, 19.5–22.5,