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Chunk #29 — Methods — Array design objectives

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Smokescreen: a targeted genotyping array for addiction research.
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The ability to customize the array was important to cover common and rare variation across populations genome-wide, with enhanced coverage in genes and regions related to addiction. Manufacturing reproducibility was also critical for translational and clinical use-cases that may be developed based on the array. Given these objectives, Affymetrix Axiom was selected as a platform for the array.