Subjects were intravenously in fused with either alcohol (6% vol/vol) or saline (placebo) in counter-balanced order as previously described (Bragulat et al., 2008). Infusion pump rates were controlled by a computer, with the infusion profile customized for each individual to achieve the same time course of breath alcohol concentration (BrAC) for all subjects: A linear ascension to 50 mg% in 10 min, followed by constant exposure at 50 mg% throughout approximate 45 minute functional image acquisition. The placebo infusion employed the same pump-rate profile to be used/as was used in the individual’s alcohol session, but infused only saline. Prior to and after imaging sessions, BrAC was measured.
