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Chunk #6 — Results — Novel BP loci in GERA and meta-analyses with ICBP and UKB

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Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
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Finally, to maximize discovery power, we combined all three studies (GERA, ICBP, and UKB, n=321,262). Our genome-wide meta-analysis of SBP, DBP, and PP had λ=1.069, 1.076, and 1.076, respectively. We identified 241 additional novel genome-wide significant loci (Supplementary Figure 6, Supplementary Table 3), although replication was not possible. Only rs139491786 showed heterogeneity evidence (I2=88, P=1.5×10−5).