Dorsolateral Prefrontal Cortex: Total RNA from 670 samples was isolated from approximately 50 mg homogenized tissue in Trizol using the RNeasy kit according to manufacturer’s protocol. Samples from all brain banks were processed together in batches of 12 and the Pitt matched case/control pairs were always processed in the same batch. 10 control samples were processed as part of both a schizophrenia and bipolar pair and therefore found as duplicate samples in the dataset. The order of extraction for schizophrenia-affected and control samples was assigned randomly with respect to brain bank, diagnosis and all other sample characteristics. Because the bipolar-affected and matched controls were not available until after the processing of the schizophrenia and controls was underway, these samples were randomized among the remaining 132 schizophrenia and control samples for extraction. The mean total RNA yield was 15.3 ug. The RNA Integrity Number (RIN) was determined by fractionating RNA samples on the 6000 Nano chip (Agilent Technologies) on the Agilent 4200 TapeStation. Samples with RIN > =5.5 were included in the sequencing set, resulting in 46 samples with RIN <
