After accounting for differences in subject total intra cranial volumes, a linked brain volume and alcohol use disorder component pair was found using parallel ICA. The alcohol use disorder component shown in Fig. 2 and the brain volume component shown in Fig. 3 have a correlation of 0.41, p < 0.05 corrected for all 21 comparisons and account for >70% of the variance in both data sets. The alcohol use disorder component is comprised most dominantly of ADScon, AUDITtot, ICSac, ICSfc and ICSpc scores, shown by their large absolute contribution weights. The positive ADScon contribution weight indicates an increase in loss of behavior control and the positive AUDITtot weight indicates an increase in the alcohol use disorder total score. The component also shows large positive ICSac weight and large negative ICSfc and ICSpc weights, which indicate increased attempts to control alcohol use coupled with decreases in success of controlling use and decreases in subject’s perception of control. This AUD component captures multiple perspectives including hazardous alcohol use and loss of control as well as perception gauging the overall severity of AUD. Hereafter we will refer to this component as the AUD severity component.
