The associated brain volume component is shown in Fig. 3 and is mainly composed of nine brain regions including cerebral whiter matter, cerebral cortex, cerebellum cortex and caudate from left and right hemispheres, and 5th ventricle (contribution weight listed in Fig. 3). Along with smaller cerebral cortex and larger cerebral white matter, specific regions are highlighted with blue representing smaller the cerebellar and caudate regions while the red represents larger 5th ventricle (cavum septum pellucidum) volumes. The significant correlation of this brain volume component to the AUD severity component implies that such brain volume variation can be a valid intermediate phenotype for genetic effect on AUD.
