The SNP-based heritability of down-sampled MOOD from LDSC was 11%, closer to PGC MDD than to PGC BD (Supplementary Table 2). Genetic correlations varied (Supplementary Tables 5 and 7) with some more similar to PGC BD (schizophrenia: down-sampled rg = 0.61, combined MDD rg = 0.35, PGC BD rg = 0.7), and others more similar to combined MDD (ADHD: down-sampled rg = 0.48, combined MDD rg = 0.45, PGC BD rg = 0.14). The genetic correlation with IQ was significant (rg = −0.13, p = 5×10−7), because the excluded 23andMe depression cohort has a positive genetic correlation with IQ (rg = 0.06, p = 0.01). The greater genetic correlation of MOOD with combined MDD (0.98) compared to PGC BD (0.55) persisted when comparing down-sampled MOOD to combined MDD (0.85) and PGC BD (0.75; Supplementary Table 6).
