We applied an additional drug repositioning method, DRUGSETS.104 Data were drawn from the Clue Repurposing Hub and the Drug Gene Interaction Database. Drug gene-sets were created for 1,201 drugs with genes whose protein products are targeted by or interact with that specific drug. Competitive gene-set analysis was performed using MAGMA v1.0841,42 while conditioning on a gene set of all drug target genes in the data (N=2,281) to test for significant associations between drug-gene sets and TUD. We applied a Bonferroni correction for the number of drug-gene sets tested (p<0.05/735=6.80E-05).
