Chunk #68 — Methods — Genetic correlation analyses.

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Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

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We estimated the within-ancestry rgs for TUD using LDSC46 and the cross-ancestry rgs for TUD across population groups using POPCORN.46 We used the ancestry-specific 1000 Genomes Project phase 378 data as the LD references.