We used local LDSC46 to calculate genetic correlations (rg) between TUD and 113 other traits or diseases.46 Local traits were selected based on previously known phenotypic associations between TUD and other substance use disorder phenotypes and related traits (e.g., cannabis use disorder, various measures of impulsivity). We used the standard Benjamini–Hochberg false discovery rate correction (FDR 5%) to correct for multiple testing. We also calculated a Bonferroni correction for 113 comparisons (p<4.42E−04); however, this correction is overly conservative because many of the traits tested are highly correlated with one another. For AA individuals, we calculated rg between TUD and 11 published traits using in-sample LD scores derived from the MVP genotype data using cov-LDSC.87
