The pathway analyses identified several pathways significantly associated with CD. The most significant canonical pathway was calcium transport in the AA case-control analysis (p = 0.002) (Supplementary Figure S2). The pathway was identified via associations in two genes encoding Ca2+-transporting ATPases, which are important for Ca2+ homeostasis: ATPase, Ca2+-transporting, plasma membrane (ATP2B2) and ATPase, Ca2+-transporting, type 2C, member 2 (ATP2C2). The highest ranked networks from both the EA Sympcountadj analysis and the AA case control analysis, and the second highest ranked network from the AA Sympcountadj model, showed associated genes (SNAP25, KCNQ4, KCNN2, and ATP2B2) with direct interactions with CALM1, which encodes calmodulin, a key calcium binding protein (Supplementary Figures S3, S4).
