We observed GWS association of CD with rs2629540 at the FAM53B (“family with sequence similarity 53, member B”) locus in the Sympcount model after removing OD, AD, and ND symptom counts as covariates (Figure 1). This was supported by evidence in both AAs and EAs. The p-value for all samples combined was 4.28×10−8 (Table 2). Under the same model, NCOR2 (nuclear receptor corepressor 1) SNP rs150954431 was associated in the EA discovery sample at the GWS level (p=1.19×10−9), but there were no consistent observations of this association in any other sample. Numerous additional SNPs were associated at the 10−7 level. We also observed GWS association of CIP with rs2456778, which maps to CDK1 (“cyclin-dependent kinase 1”), in the AA discovery sample (p=4.68×10−8). This association nearly reached nominal significance in the EA discovery sample (p=0.0502) and was slightly improved in the two populations combined (p=4.26×10−8), but was not well supported in the Phase 3 replication sample. Phenotypic data for CIP were not available for SAGE. Additional associations (p<1×10−6) were observed with numerous other SNPs in AAs, EAs or in both groups combined (Table 2). (Manhattan plot and associated Q/Q plot, Figures 2 and 3; Complete results, Supplementary Table 3).
