Chunk #105 — III. Selected Methodological Issues — C. Analyses — 1. Achieving significant genome wide association in single samples vs seeking replication and generalization in multiple samples

Source

Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

Embedded

yes

Text

We thus a) first identify nominally-significant SNPs in each sample, 2) identify the clustering of such SNPs (within small chromosomal regions) in each sample, 3) seek replication, identifying small genomic areas in which clusters from multiple replicate samples from the same phenotype also identify clustered nominally-significant SNPs 4) seek generalization, identifying genes that contain clusters of nominally-positive SNPs from studies of related, genetically determined phenotypes.