We observed hyper-connectivity in the set driven by drinking associated with the rsFNC between lingual/cerebellar vermis and putamen. For this pair, the rsFNC was higher for the DRN group than for any of the other three groups. This observation points to an abnormal influence over the brain reward system known to be affected by alcohol (Di Chiara, 1997). In particular, the putamen is an area where an increase of dendritic spine density and an enhancement of glutamatergic transmission was linked to alcohol in primates (Carlson et al., 2011). This neuroadaptation could in part explain an increase of connectivity related to the putamen. A different result was obtained for the insula where hypo-connectivity was observed. Since the insula is an area known to be involved in interoception of bodily functions (Craig, 2003), insula hypo-connectivity observed in our results is consistent with reduced interoceptive awareness previously linked to alcohol addiction (Çöl et al., 2016). Hypoconnectivity within the insula has been previously reported and hypothesized as playing a role in alcohol relapse because of a diminished awareness of substance use (Camchong et al.,
