Of the markers measured in the current study, the most associated SNP with level of response to alcohol, rs10776687, is in complete linkage disequilibrium (LD) with the c1 allele of CYP2E1*5B, rs2031920, implying that this marker is associated with the level of response to alcohol as well. A homozygous genotype of the minor allele c2 of CYP2E1*5B is associated with an increase in gene transcription (Watanabe et al., 1994). Another marker, rs2515641, is in complete LD with rs2070676, also known as CYP2E1*1B.
