This study had a number of methodological strengths, particularly confirming the presence or absence of a family history of alcoholism, assessing a range of measures, testing placebo and more than one dose of alcohol, and prospectively tracking and confirming menstrual cycle phase. Despite these strengths, there were several limitations. First, hormone levels to confirm menstrual cycle phase were only obtained for 87% of the women because some women refused to have blood drawn or we had technical difficulties drawing blood samples. Despite keeping accurate prospective records of their menstrual cycles and having women do urinary ovulation kits, hormone levels are still the gold standard for verifying menstrual cycle phase. Second, the two groups were not matched on level and pattern of alcohol consumption, that has been the standard approach in alcohol challenges studies comparing FHN and FHP individuals (e.g., Eng et al., 2005; King et al., 1997; McCaul et al., 1991b). It was our original intention to match FHN and FHP women on drinking behavior, by recruiting only light drinkers, as we have successfully done in previous studies (Evans et
