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Chunk #44 — 4. Discussion

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Changes in gene expression within the extended amygdala following binge-like alcohol drinking by adolescent alcohol-preferring (P) rats.
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significantly decreased by adolescent binge-like drinking in the present study. The contrast in the results between the present study and the findings of Coleman and colleagues (2011) could be due to a combination of factors: (a) i.g. bolus administration of ethanol, which produced BELs of ~280 mg% vs. binge-like drinking, which produced BELs of ~100 mg%; (b) whole brain vs. discrete regions; and/or (c) inbred mouse vs. selectively bred rat.