The effects of repeated i.g. administration of ethanol (5 g/kg once per day for 10 consecutive days) during adolescence (PND 28 – 37) were studied on changes of gene expression in the whole brain of C57BL/6 mice (Coleman et al., 2011). In this study, RT-PCR arrays targeting genes for different peptide, cholinergic, monoamine, GABA and glycine receptors were used. In general, measurements taken on PND 38 indicated reduced expression of genes for these receptors in the ethanol-treated group compared to the controls. These findings are in contrast to the present results where expression of genes for different receptors were increased in the Acb-sh (Adora2b, Adrb2, Npy5r; Supplemental Table A) and CeA (Gabrb3, Grm7, Hrh3, Htr1d, Npy5r, Tfrc; Supplemental Table B) of the binge drinking group vs. the water control. In no case was the expression of genes for any receptor significantly decreased by adolescent binge-like drinking in the present study. The contrast in the results between the present study and the findings of Coleman and colleagues (2011) could be due to a combination of factors: (a) i.g. bolus administration of
