Overall, the effects of binge drinking by P rats on gene expression appear to be age and region dependent. Although there are some biological systems in common between the effects of adolescent vs. adult ethanol intake, there are few genes in common within these systems, suggesting different mechanisms of action and their associated outcomes at the 2 different ages. Moreover, there was only one biological system in common between the 2 regions, which likely reflects the different inputs to and neuronal circuits within the Acb-sh vs, the CeA.
