This methodology of clinical pathological associations has generated further evidence on neural substrates of social cognition related to hemispheric specialization. Most notable for case reports were the documentation of prosodic disturbance associated with right hemispheric lesion (Ross and Mesulam 1979), and of deteriorating social functioning in a case of right frontal damage in a railroad worker (Damasio et al. 1994). Aggregate case reports by Gainotti (1972) noted dysphoria and anti-social behavior with left hemispheric lesions, and jocularity and euphoria with right hemispheric lesions. Sackeim et al. (1982) reported retrospective studies of 119 cases of pathological laughing and crying associated with destructive lesions. Pathological laughing was associated with right-sided damage, whereas pathological crying with left-sided lesions. In 19 reports detailing mood following hemispherectomy, right hemispherectomy was associated with euphoric mood change. In reports of 91 patients with ictal outbursts of laughing (gelastic epilepsy), foci were predominantly left-sided. These case reports converged to suggest predominant role of the right hemisphere in mood regulation, with an overlay of left hemispheric involvement in positive affect. Other clinical-pathological association studies, closely linked with animal studies,
