We further explored the 4 most recurrent altered regions (>20), which also harbor well known cancer genes (as noted in the COSMIC22 and Mitelman databases: http://cgap.nci.nih.gov/Chromosomes/Mitelman); these were on chromosomes 9p (cnloh), 13q (del), 14 (cnloh) and 20q (del) (Table 4). Notably, the most recurrent mosaic events were observed in cancer-free individuals as well as across multiple solid tumors. We observed a comparable frequency in non-hematologic cancer cases and cancer-free controls for three of the regions, whereas the chromosome 14 cnloh abnormalities were more frequent in non-hematological cancer cases (OR=3.32, 1.42-9.00 95% CI, Fisher’s exact p=0.003), particularly in individuals with bladder or kidney cancer. Copy-neutral loh in this region of chromosome 14 has been associated with increased susceptibility to sporadic cancers and harbors imprinted genes, such as the tumor suppressing non-coding RNA, Maternally expressed gene 3 (MEG3)8,23. The recurrent segmental deletion of 13q14 was observed in 5 leukemia cases, but also in 18 individuals with solid tumors (9 with lung cancer and 4 with prostate cancer), and in 10 cancer-free individuals. This region includes the tumor suppressor gene DLEU7 (Deleted
