For exclusion, the following criteria were defined: (1) review-studies, meta-analyses, and re-analyses, (2) region of interest analyses, small volume corrected results, and investigations with only partial brain coverage, (3) methodological studies and study protocols, (4) studies with small sample sizes (<10 per group) and (5) studies with statistical approaches not correcting for multiple comparisons or setting a minimum cluster extension as a statistical threshold for significance. Unlike conventional meta-analytical methods, (6) studies reporting null-findings could not be taken into account because they do not provide spatial coordinates, which are a prerequisite for coordinate-based meta-analyses. (7) Studies investigating patient groups with Korsakoff syndrome, with other primary psychopathology or comorbid other substance use disorder (except for tobacco).
