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Chunk #18 — MATERIALS AND METHODS — Statistical Analyses

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Evidence of CNIH3 involvement in opioid dependence.
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yes

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Statistical analyses of the imaging data were conducted using linear regression in SPSS to test the association between rs10799590 A allele carrier status and amygdala habituation (i.e., declining amygdala response to repeated stimuli). To maintain variability but constrain the influence of extreme outliers, all imaging variables were winsorized prior to analyses. Gender and psychiatric diagnosis (0,1) were entered as covariates for analyses. To determine whether rs1079950 was most strongly associated with amygdala habituation within this genomic region, SNPs ± 100 kbp that had an LD r2 ≥ .50 with rs10799590 within the dataset were identified and binned according to LD (r2 ≥ .80). Similar analyses were then conducted to examine the association between carrier status of each SNP and amygdala habituation.