First, we meta-analyzed all available GWASs (AGGoverall). Second, we meta-analyzed all available data within rater (rater-specific GWAMAs). Third, rater-specific age-bins were created for mother- and self-reported AGG based on the mean ages of the subjects in each GWAS (age-specific GWAMA). To ensure that the age-specific GWAMAs would have sufficient power for subsequent analyses, age-bins were created such that the total univariate number of observations (Nobs) exceeded 15 000 (see Supplementary text and Supplementary Table 12). For father- and teacher-reported AGG, there were insufficient data to run age-specific GWAMAs. Fourth, we performed instrument-specific GWAMAs for (1) the ASEBA scales and (2) for the SDQ, because for these two instruments the total univariate Nobs was over 15 000.
