Chunk #39 — Methods and results — Testing for significance of gene-environment interaction effects using the reparameterized equation

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Testing for measured gene-environment interaction: problems with the use of cross-product terms and a regression model reparameterization solution.

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a classic genetic model (additive, dominant, or recessive) should be viewed skeptically without a clear reason why a more complex genetic model is appropriate for that study. We have listed the situations in which one would conclude that a significant G × E is supported by the data and the likely genetic model associated with the interaction (Fig. 3).