of block 1 (rs4587976-rs1071502-rs1366076) revealed significant association of haplotypes GAT (protective) and CAT (risk), (uncorrected P =9.6E-05 and 0.0036, respectively, Table 3). The association test of the GAT haplotype was close to significance after correction for multiple testing (P = 0.058). The contributing SNP to this effect is rs4587976 (C as a risk allele, G as a protective allele) in concordance with the single SNP analysis. Multi-locus genotype pattern analysis of this block revealed a significant difference between cases and controls with a similar effect, uncorrected P = 0.0005, data not shown).
