Chunk #14 — Material and methods — I. Heroin self-administration, extinction, foot shock- and heroin- induced reinstatement — 4. Procedure — (B) Extinction

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Individual differences in gene expression of vasopressin, D2 receptor, POMC and orexin: vulnerability to relapse to heroin-seeking in rats.

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Forty-eight hours after the last heroin self-administration session, extinction occurred over four 3-h sessions (days 9–12, see Fig. S1). Extinction sessions were identical to the self-administration sessions except that saline was substituted for heroin.