We used pathway analysis to characterize the hypotheses that guided candidate gene selection. The 732 hypothesis-driven candidate genes were entered into DAVID to assess the Gene Ontology biological processes to which these genes belonged. The top four annotation clusters consist of biological processes involved in synaptic transmission, neuronal development and morphogenesis, regulation of synaptic transmission, and response to chemical stimuli (Tables 1 and S2). The full list reflects a diversity of ideas about schizophrenia etiology; as expected, cluster enrichment scores were particularly strong for candidate genes selected under the hypotheses that schizophrenia is a disease of the synapse and/or a neuro-developmental process.
