Table 1 describes hypothesis-driven candidate genes from SZGene (Allen et al., 2008). There were 732 autosomal genes from 1,374 hypothesis-driven candidate gene studies (Table S1). These genes were studied from 1–81 times. Most genes (563, 76.9%) were investigated in one (60.9%) or two studies (16.0%). Although replication is critical in human genetics, there is little capacity to evaluate both false positive and false negative findings. Two-thirds of genes were assessed by ≤3 markers and a median SNP density of 15.4 kb/SNP. The median numbers of cases (191) and controls (214) were modest.
